Drug Improves Kidney Function In Diabetics Pentoxifylline Prevents Protein Leakage Into Urine

�Pentoxifylline, a drug victimized to
handle patients with circulation problems, may as well benefit those with
kidney disease caused by diabetes and other conditions. Specifically,
pentoxifylline decreases proteinuria, the abnormal outflow of protein
into the urine, according to 2 articles in the September issue of the
American Journal of Kidney Diseases, the official journal of the
National Kidney Foundation.



"When kidneys are healthy, very slight or no protein appears in the
urine," says Dr. Kerry Willis, Senior Vice President for Scientific
Activities at the National Kidney Foundation. "Protein in the weewee
is an early sign that the kidney's filters have been damaged by
disease, allowing protein to leak into the pee."



Pentoxifylline makes red blood cells more than flexible to improve
circulation in the smallest blood vessels of the body. It besides has
anti-inflammatory drug properties. Several small clinical trials make
suggested that the drug decreases proteinuria caused by diabetes.



A research team at the Kidney Research Centre and the Ottawa Health
Research Institute in Ontario, Canada, combined information from 10 of these
studies to get a better estimation of scarce how effective pentoxifylline is in
diabetic patients.



A total of 476 patients were treated for close to 6 months.
Pentoxifylline substantially reduced proteinuria, particularly in
patients with the highest levels of urine protein.



According to lead author Dr. Brendan B. McCormick, "Proteinuria is a
substantial risk agent for kidney failure, and by decreasing proteinuria,
pentoxifylline may help in reducing the likeliness that a diabetic
patient will terminal up needing dialysis."



In two of the trials, pentoxifylline was as effective as capoten, a
type of dose called an ACE inhibitor used to treat high blood atmospheric pressure
and to protect kidneys in diabetic patients. This property whitethorn be
especially beneficial in patients wHO cannot acquire ACE inhibitors
because of their side effects.



In the second paper, Dr. Tun-Jun Tsai and colleagues at National Taiwan
University Hospital in Taipei took this construct even further, looking at
how well pentoxifylline worked in concert with losartan, another ACE
inhibitor. The 85 patients had advanced kidney disease due to diabetes
and to glomerulonephritis, a group of diseases that crusade inflammation
and damage to the kidney's filtering units.



After one year, proteinuria was reduced by an additional 40%.



An additive effect 'tween pentoxifylline and ACE inhibitors is
important, Dr. Tsai's group points out, because ACE inhibitors and
drugs like them often lose their effects over time, and pentoxifylline
represents a nontoxic choice for boosting their effectiveness.



Authors of both reports call for larger trials to confirm their
findings, and to see if pentoxifylline actually stops kidney disease
progress.



"A positive finding in this setting would be of profound significance
because it would provide a novel and inexpensive therapy for the growing
orbicular epidemic of diabetic nephropathy," Dr. McCormick's team
concludes.

The National Kidney Foundation is dedicated to preventing and treating
kidney and urinary parcel diseases, improving the health and well being
of individuals and families affected by these diseases and increasing
accessibility of all organs for transplantation.

The National Kidney Foundation


View drug information on Captopril and hydrochlorotiazide; Pentoxifylline.



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Psychedelic Horseshit, New Wave Hippies Single Review

Single Review of 'New Wave Hippies' by Psychedelic Horseshit.

Matt (Sing,guitars) and Rich (Drums,shoes) from Columbus, Ohio are "The Shit", a duo world Health Organization have spent much of their formative years patently listening to the art rock of early Sonic Youth and coveting the dishevellment of Beck.

It would be easy to dismiss New Wave Hippies as a joke - it opens with a mercifully brief cod-reggae jam (Dub Gaze) and closes with a demo quality krautrock collage (Magick Defends Itself Pt. 3) - whilst in between on that point are squalls of misdirected feedback and song writing so brittle a dozen year old wouldn't devastate it on their MySpace. Of sole interest is the claim track, which sounds vaguely like a roughed up Suicide and contains the magic

Cinema Expo closes on upswing

Organizers tout upturns in attendance

AMSTERDAM -- After four days of high-profile screenings, receptions themed to promote studio slates and seminars devoted to all things digital, Cinema Expo 2008 wound to a close Thursday with organizers touting upturns in attendance and trade show participation.


Attendance rose more than 6% this year to 1,150 paid registrations.


"We're thrilled with the attendance, and the reason people come here is to check out what's going on in the industry," confab co-managing director Robert Sunshine said. "The industry is changing right now, and that change is digital cinema."


D-cinema also figured big on the confab's large trade show floor, which boasted 210 booths this year, seven more than a year ago.


A strong euro made this year's show particularly affordable, though currency rates also meant that Cinema Expo's U.S. organizers absorbed higher costs in paying for local goods and services with weak American dollars.


Cinema Expo -- owned and operated by a unit of the Nielsen Co., parent of The Hollywood Reporter -- is set to return to its longtime home at the RAI convention center on June 22-25, 2009. Organizers said they didn't expect much impact from a new summer trade show planned for Brussels next year by the International Union of Cinemas, and Hollywood studios have indicated continued support for Cinema Expo.


Cinema Expo's film screenings this year included Warner Bros.' summer tentpole "The Dark Knight," set for a day-and-date bow in most global territories July 18. And the most elaborate dinner event of the week was a reception that Paramount tied to a screening of its August combat comedy "Tropic Thunder," turning a banquet hall into a mist-filled jungle featuring a helicopter, jeeps and hostesses clad in fatigues.


Discussions about d-cinema figured prominently. In Europe, even such core issues as funding and operation remain to be sorted out.


Studios finally have locked down European virtual print fee agreements -- basically arrangements for the majors to help defray much of the $100,000 or so in d-cinema installation costs. It's believed that the closely guarded terms of the regional VPFs are about one-third less generous than what was on offer in the first such deal in the U.S., though scuttlebutt suggests a similar retrenchment in studio largesse there for those arriving late to the VPF party.

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Jermaine Dupri and Janet Jackson To Start Family

Jermaine Dupri has revealed that he wants to start a family with his longtime partner Janet Jackson, saying they’ll try once her latest tour has wrapped.
The uber-producer told People over the weekend, “Yeah soon,” when asked if they’re thinking of having children, “Right after the tour.”
Jackson, 42, is about to embark on a North American tour after recently canceling planned European performances, due to a conflict with her record company which has prevented any further singles being released from her ‘Discipline’ album.
“Janet would be a great mom,” Dupri continues.� “She was around so many brothers and sisters all her life, so she’s got to know what that is [like]. And her mom is a great mother.”
Photo courtesy of So So Def.

Thomas Kretschmann - The Things They Say 8620

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90210 spin-off series gets its Dad

The actor who will play the father character in the 'Beverly Hills, 90210' spin-off, '90210', has been announced.
The Hollywood Reporter says that actor Rob Estes will play Harry Mills in the new series.
He is a school principal who moves his family from Kansas to take over at West Beverly High.
The new series is the second 'Beverly Hills, 90210' spin-off for Estes; he previously played Kyle McBride on 'Melrose Place'.
Among his other credits are 'CSI: Miami' and 'Suddenly Susan'.

New movie deal for wrestling stars

World Wrestling Entertainment has inked a first-look deal with 20th Century Fox, which will allow the movie giant the right to distribute films starring WWE stars.
From 2009, WWE Films plans to release one new movie in cinemas and four straight-to-DVD annually.
The first film under the new deal will be '12 Rounds', which will star wrestler John Cena and will be released in 2009.
Production on '12 Rounds' begins in New Orleans in March.
WWE wants to make films across all genres that will appeal to a broader audience.

Guns N' Roses to release album for Father's Day...

Guns N' Roses to release album for Father's Day...

Guns N Roses ar re-releasing their 'Greatest Hits' album, evidently in time for Father's Day (June 15).

According to a press waiver around the record album which will be reissued on June 2, the collection is out over again "particularly for Father�s Day, as it's most unquestionably the only record album of pick for any serious rockfather".

However, there is still no definitive news whether Axl Rose's long-delayed 'Chinese Democracy' volition come in come out in 2008 after it was plainly finished.

The 'Greatest Hits' album features the following tracks:

'Welcome To The Jungle'
'Sweet Child O' Mine'
'Patience'
'Paradise City'
'Knockin' On Heaven�s Door'
'Civil War'
'You Could Be Mine'
'Don't Cry (Archetype)'
'November Rain'
'Live And Rent Die'
'Yesterdays'
'Ain't It Fun'
'Since I Don�t Have You'
'Sympathy For The Devil'






Mac Dowell and Krell

Paris Hilton's Mom To Star In Soap Opera

Paris Hilton's Mom To Star In Soap Opera

Kathy Hilton, mother of socialite's Paris and Nicky Hilton, is set to play herself in an upcoming episode of television liquid ecstasy opera 'The Edward Young and the Restless'. According to The Associated Weigh, Hilton plays a type world Health Organization finds a magazine publisher report mannequin for Jack Abbott, played by Simon Peter Ingrid Bergman. However, his married woman Phyllis becomes angry when Labourer permits Hilton's character to take over the photo take. Hilton taped the sequence on Wednesday (April 16), with a cover escort so far to be announced.Pic courtesy of NBC.  Taken by Craig Blankenhorn.

Daniel Day-Lewis to present DGA award

Daniel Day-Lewis to present DGA award

Wicklow resident Daniel Day-Lewis has been confirmed by the President of the Directors Gild of America, Michael Apted, as single of the presenters at the upcoming DGA awards.
Day-Lewis has been nominated for an Academy Award for Best Doer for his Golden Ball winning role in 'There Testament Be Blood'.
This is his fourth nomination for the award, which he antecedently won in 1990 for his performance as Christy Brown in 'My Left Foot'.
Other Academy Award nominees wHO will join Day-Lewis in presenting the DGA awards include: Marion Cotillard, Amy Ryan, Tilda Swinton, Tom Wilkinson, Hal Holbrook and Ellen Page.
'Ocean's Eleven' star Carl Reiner will render as host for the 60th annual DGA awards. This class testament marker the 21st time Reiner has hosted the ceremony, which will take blank space on Sabbatum 26 January in Los Angeles. 




Orchestra 'lautarii'

Lohan to work in morgue as punishment

Lohan to work in morgue as punishment

Actress Vachel Lindsay Arhat will work at a dead room as role of her penalty for a drink-driving offensive activity.
The 21-year-old star topology volition complete the work-placement as component of a court-ordered course of study, in which she mustiness hear some the dangers of drink-driving.
According to reports, Lohan is due to spend deuce four-hour years at the morgue, as easily as completing a stint workings in a hospital emergency elbow room.
The actress was arrested twice last twelvemonth on charges of drive while under the influence. In August she pleaded guilty to infringement drunken driving and cocain charges.
Arhat served 84 minutes of her 24-hour jailhouse sentence end Nov. She must at present nail an alcoholic drink education programme and execute 10 years of community service.

Court now orders Spears psych exam

Court now orders Spears psych exam

A judge has ruled that troubled pop star Britney Spears must be examined by a court-appointed shrink to find out if she understands the legal minutes involving her.
Reuters reports that Los Angeles Superior Motor hotel Commissioner Scott Gordon ordered on Monday that the psychiatrist file a news report on the 26-year-old's mental consideration by 13 February.
On 14 Feb it volition be decided how practically thirster Spears' assets should persist under the temp control of her fatherhood and his lawyer.
Commissioner Gordon besides said that a restraining decree against Spears' self-styled manager and intimate, SAM Lutfi, forbids him from any form of contact lens with her.
Spears was taken to the UCLA Health check Shopping center for a 72-hour psychiatric evaluation last calendar week; her stay has now been extended to two weeks.




Stereophonics

Fans beg Winehouse to quit drugs after video

Fans beg Winehouse to quit drugs after video

Fans of troubled singer Amy Winehouse have begged her to catch help after she was caught on television apparently smoke crack cocain.
Footage obtained by The Sun appears to show her inhaling fumes from a crack pipe afterward an apparent 19-minute drugs splurge in which she snorted adam, cocain and admitted to pickings Valium tablets.
The disturbing images were said to accept been filmed during a party at Winehouse's British capital home in the early on hours of last Friday, hardly ahead she attended a judicature hearing for hubby William Blake Fielder-Civil. He is awaiting test on charges of assault and confederacy to pervert the trend of justice.
Looking dishevelled and eating away a myxocephalus aenaeus black vest in the video, Winehouse was scarce able to speak. When friends ask her to go come out with them, she is heard to response: "I'd be useless to you because I've had around six-spot Diazepam."
On the singer's website, fans warned the 24-year-old that she would die unless she sought help.
1 fan said: "That video of you at home, which is now doing the rounds, testament hopefully be instrumental in getting you where you pauperization to be."
The fan quoted the mother of the late Enlightenment front man man Kurt Cobain, warning Winehouse non to "join that pudding head gild" of dead rock and roll stars.